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Welcome to the Western Sydney Local Health District Digital Repository
The WSLHD Digital Repository is an institutional repository managed by WSLHD Libraries. This repository stores and showcases the research output of our staff and preserves our historical collection of archival material. If you are a current member of staff of Western Sydney Local Health District and wish to submit to this repository, please contact your facility library.Recent Submissions
BACKGROUND AND AIMS: Although there has been limited improvement in 5-year survival of advanced tubo-ovarian highgrade serous carcinoma (HGSC), surprisingly little attention has been paid to directly studying patients with exceptionally poor prognosis. Clinicopathological and multi-omics features of HGSC were compared in BRCA1/2-mutant and BRCA-wildtype patients with short- and long-term survival to identify factors influencing clinical outcome. METHODS: Whole-genomesequencing, RNA-sequencing...
The kinase activity of human inositol phosphate multikinase (IPMK) is required for the synthesis of higher-order inositol phosphate signaling molecules, regulation of gene expression, and control of the cell cycle. Here, we report a novel series of highly potent IPMK inhibitors. The first-generation IPMK inhibitor 1 (UNC7437) decreased cellular proliferation and tritiated inositol phosphate levels in metabolically labeled human U251-MG glioblastoma cells. It also impacted the transcriptome of...
Communities in the repository
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- 1385 Auburn
- 4267 Blacktown
- 341 Mental Health Services
- 262 Mount Druitt
- 238 Western Sydney Local Health District
- 7440 Westmead
- 6149 2020 - 2029
- 1233 2010 - 2019
- 199 2000 - 2009
- 32 1990 - 1999
- 14 1980 - 1989
- 7 1970 - 1979
- 1 1965 - 1969
- 735 Oncology
- 667 Cardiology
- 335 Infections
- 256 Surgery
- 246 Pharmacology
- 232 Allied Health
- 200 Neurology
- 183 Mental Health
- 178 Hepatology
- 171 Nephrology
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