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DC Field | Value | Language |
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dc.contributor.author | Bhaskaran, Ashwin | - |
dc.contributor.author | Campbell, Timothy G. | - |
dc.contributor.author | Virk, Sohaib | - |
dc.contributor.author | Bennett, Richard G. | - |
dc.contributor.author | Kizana, Eddy | - |
dc.contributor.author | Kumar, Saurabh | - |
dc.date.accessioned | 2022-07-20T06:13:19Z | - |
dc.date.available | 2022-07-20T06:13:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Cardiovascular Electrophysiology 32(5):1421-1429, 2021 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/4246 | - |
dc.description.abstract | BACKGROUND: Non-compaction cardiomyopathy (NCCM) is a form of structural heart disease prone to ventricular arrhythmias (VAs) and sudden cardiac death. Non-compacted myocardium may harbor VA substrate, though some reports suggest otherwise. OBJECTIVE: This study aimed to characterize the electrophysiologic (EP) features of VA in NCCM. | - |
dc.description.abstract | METHODS: We performed a systematic review of case reports, case series, and observational studies. RESULTS: One hundred and thirty-five cases of NCCM from studies between 2000 and 2020 were included. Mean age was 34 +/- 20 years, mean left ventricular (LV) ejection fraction was 42 +/- 15% with two cases having late gadolinium enhancement on magnetic resonance imaging. The LV apex was the most common non-compacted segment (86%); 10% involved the right ventricle (RV). Antiarrhythmic failure was documented in 16 cases, of which 50% failed more than one agent. Only 23% of monomorphic VAs localized to regions of non-compaction on electrocardiogram. Most frequently, VAs localized to the RV outflow tract (n = 21), posterior fascicle (n = 19), and anterolateral LV apex (n = 9). All cases with apical exits arose from the non-compacted myocardium. On EPS, 83% of sustained VTs were due to re-entry, 17% due to focal mechanism. Catheter ablation was performed in 39 cases, with 7 requiring more than 1 procedure. Acute VA non-inducibility was achieved in 82% and VA-free survival was reported in 85% over a mean follow-up of 24 months. CONCLUSION: The majority of VAs in NCCM arise remotely from non-compacted myocardium, and non-re-entrant mechanism seen in ~1/5th of sustained VTs. Catheter ablation outcomes appear favorable. Further study is needed to understand the pathophysiology of VA in NCCM. | - |
dc.title | Electrophysiologic and electroanatomic characterization of ventricular arrhythmias in non-compaction cardiomyopathy: A systematic review | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1111/jce.15026 | - |
dc.subject.keywords | Arrhythmias, Cardiac | - |
dc.subject.keywords | Cardiomyopathies | - |
dc.subject.keywords | Catheter Ablation | - |
dc.subject.keywords | Contrast Media | - |
dc.subject.keywords | Gadolinium | - |
dc.subject.keywords | Tachycardia, Ventricular | - |
dc.identifier.journaltitle | Journal of Cardiovascular Electrophysiology | - |
dc.contributor.wslhd | Bhaskaran, Ashwin | - |
dc.contributor.wslhd | Campbell, Timothy G. | - |
dc.contributor.wslhd | Virk, Sohaib | - |
dc.contributor.wslhd | Bennett, Richard G. | - |
dc.contributor.wslhd | Kizana, Eddy | - |
dc.contributor.wslhd | Kumar, Saurabh | - |
dc.type.studyortrial | Research Support, Non-U.S. Gov't | - |
dc.type.studyortrial | Systematic Review | - |
dc.identifier.pmid | 33792994 | - |
dc.identifier.facility | Westmead | - |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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