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DC Field | Value | Language |
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dc.contributor.author | Stemler, J. | - |
dc.contributor.author | Lackner, M. | - |
dc.contributor.author | Chen, Sharon C-A. | - |
dc.contributor.author | Hoenigl, M. | - |
dc.contributor.author | Cornely, O. A. | - |
dc.date.accessioned | 2023-04-06T00:38:43Z | - |
dc.date.available | 2023-04-06T00:38:43Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Antimicrobial Chemotherapy 77(1):253-258, 2021 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/6713 | - |
dc.description.abstract | BACKGROUND: Invasive scedosporiosis and lomentosporiosis are life-threatening fungal infections in immunocompromised patients with complex diagnostic and treatment patterns. OBJECTIVES: To develop a scoring tool to facilitate and quantify adherence to current guideline recommendations for diagnosis, treatment and follow-up of invasive scedosporiosis and lomentosporiosis. METHODS: Experts from European Confederation of Medical Mycology (ECMM) excellence centres reviewed current guidelines for scedosporiosis and lomentosporiosis. Recommendations for diagnosis, treatment and follow-up were summarized, assembled and weighted according to their strength of recommendation and level of evidence (strongly recommended = 3 points; moderately recommended = 2 points; marginally recommended = 1 point; recommended against = 0 points). Additional items considered of high importance for clinical management were also weighted. RESULTS: A total of 170 recommendations were identified. A 21-item tool was developed and embedded into the EQUAL score card. Nine items for diagnosis with 18 achievable points were assembled. For treatment, three general recommendation items with a maximal score of 9 were identified, while for specific antifungal treatment the two fungal pathogens were separated. Three and four items were established for scedosporiosis and lomentosporiosis, respectively, with a maximum achievable score of 3 due to the separation of different treatment options with the maximum point value of 3 for voriconazole-based treatment. Follow-up comprised two items (4 points maximum). Key recommendations for clinical outcome were weighted accordingly. CONCLUSIONS: We propose the EQUAL Score Scedosporiosis/Lomentosporiosis to quantify adherence to current guideline recommendations for management of these rare infections. The score remains to be validated in real-life patient cohorts and correlated with patient outcome. | - |
dc.title | EQUAL Score Scedosporiosis/Lomentosporiosis 2021: a European Confederation of Medical Mycology (ECMM) tool to quantify guideline adherence | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1093/jac/dkab355 | - |
dc.subject.keywords | Antifungal Agents | - |
dc.subject.keywords | Guideline Adherence | - |
dc.subject.keywords | Invasive Fungal Infections | - |
dc.subject.keywords | Mycology | - |
dc.identifier.journaltitle | Journal of Antimicrobial Chemotherapy | - |
dc.identifier.department | Infection Prevention and Control | - |
dc.contributor.wslhd | Chen, Sharon C-A. | - |
dc.type.studyortrial | Research Support, N.I.H., Extramural | - |
dc.type.studyortrial | Research Support, Non-U.S. Gov't | - |
dc.identifier.pmid | 34542613 | - |
dc.identifier.facility | Westmead | - |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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