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https://wslhd.intersearch.com.au/wslhdjspui/handle/1/7273
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DC Field | Value | Language |
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dc.contributor.author | McNamee, Nicholas | - |
dc.contributor.author | da Silva, Ines Pires | - |
dc.contributor.author | Nagrial, Adnan M. | - |
dc.contributor.author | Gao, Bo | - |
dc.date.accessioned | 2023-06-23T06:39:03Z | - |
dc.date.available | 2023-06-23T06:39:03Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | International journal of molecular sciences 24(9):8129, 2023 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/7273 | - |
dc.description.abstract | Small-cell lung cancer (SCLC) is an aggressive disease with distinct biological and clinical features. The clinical course of SCLC is generally characterised by initial sensitivity to DNA-damaging therapies, followed by early relapse and broad cross resistance to second line agents. Whilst there has been an enormous expansion of effective targeted and immune-based therapeutic options for non-small cell lung cancer (NSCLC) in the last decade, little improvement has been achieved in SCLC treatment and survival due, at least in part, to underappreciated inter- and intra-tumoral heterogeneity. Here we review the current treatment paradigm of SCLC including recent advances made in utilizing immunotherapy and the challenges of identifying a predictive biomarker for immunotherapy response. We examine emerging new targeted therapies, combination immunotherapy and future directions of SCLC treatment research. | - |
dc.title | Small-cell lung cancer - an update on targeted and immunotherapies | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.3390/ijms24098129 | - |
dc.subject.keywords | Lung Neoplasms | - |
dc.subject.keywords | Carcinoma, Non-Small-Cell Lung | - |
dc.subject.keywords | Immunotherapy | - |
dc.identifier.journaltitle | International journal of molecular sciences | - |
dc.identifier.department | Oncology | - |
dc.identifier.pmid | 37175833 | - |
dc.contributor.wslhd | McNamee, Nicholas | - |
dc.contributor.wslhd | da Silva, Ines Pires | - |
dc.contributor.wslhd | Nagrial, Adnan M. | - |
dc.contributor.wslhd | Gao, Bo | - |
dc.identifier.affiliation | Blacktown and Westmead Hospitals, Sydney, NSW, Australia | - |
dc.identifier.affiliation | Westmead Clinical School, University of Sydney, Sydney, NSW, Australia | - |
dc.identifier.facility | Blacktown | - |
dc.identifier.facility | Westmead | - |
dc.type.studyortrial | Review | - |
Appears in Collections: | Blacktown Mount Druitt Hospital |
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