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DC Field | Value | Language |
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dc.contributor.author | Mekapogu, A. R. | - |
dc.contributor.author | Xu, Z. | - |
dc.contributor.author | Pothula, S. | - |
dc.contributor.author | Perera, C. | - |
dc.contributor.author | Pang, Tony | - |
dc.contributor.author | Hosen, S. M. Z. | - |
dc.contributor.author | Damalanka, V. | - |
dc.contributor.author | Janetka, J. | - |
dc.contributor.author | Goldstein, D. | - |
dc.contributor.author | Pirola, R. | - |
dc.contributor.author | Wilson, J. | - |
dc.contributor.author | Apte, M. | - |
dc.date.accessioned | 2023-09-28T14:00:04Z | - |
dc.date.available | 2023-09-28T14:00:04Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Cancer Letters 568:216286, 2023 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8176 | - |
dc.description.abstract | Pancreatic cancer (PC) is a deadly cancer with a high mortality rate. The unique characteristics of PC, including desmoplasia and immunosuppression, have made it difficult to develop effective treatment strategies. Pancreatic stellate cells (PSCs) play a crucial role in the progression of the disease by interacting with cancer cells. One of the key mediators of PSC - cancer cell interactions is the hepatocyte growth factor (HGF)/c-MET pathway. Using an immunocompetent in vivo model of PC as well as in vitro experiments, this study has shown that a combined approach using HGF/c-MET inhibitors to target stromal-tumour interactions and chemotherapy (gemcitabine) to target cancer cells effectively decreases tumour volume, EMT, and stemness, and importantly, eliminates metastasis. Notably, HGF/c-MET inhibition decreases TGF-beta secretion by cancer cells, resulting in an increase in cytotoxic T-cell infiltration, thus contributing to cancer cell death in tumours. HGF/c-MET inhibition + chemotherapy was also found to normalise the gut microbiome and improve gut microbial diversity. These findings provide a strong platform for assessment of this triple therapy (HGF/c-MET inhibition + chemotherapy) approach in the clinical setting. | - |
dc.title | HGF/c-Met pathway inhibition combined with chemotherapy increases cytotoxic T-cell infiltration and inhibits pancreatic tumour growth and metastasis | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1016/j.canlet.2023.216286 | - |
dc.subject.keywords | Hepatocyte Growth Factor | - |
dc.subject.keywords | Proto-Oncogene Proteins c-met | - |
dc.subject.keywords | Cell Line, Tumor | - |
dc.subject.keywords | Pancreatic Neoplasms | - |
dc.subject.keywords | T-Lymphocytes | - |
dc.identifier.journaltitle | Cancer Letters | - |
dc.contributor.wslhd | Pang, Tony | - |
dc.type.studyortrial | Research Support, Non-U.S. Gov't | - |
dc.identifier.pmid | 37354984 | - |
dc.identifier.facility | Westmead | - |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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