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DC Field | Value | Language |
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dc.contributor.author | George, Rachna | - |
dc.contributor.author | Krishnan, Vijay | - |
dc.contributor.author | Talbot, Daniel | - |
dc.contributor.author | Elhindi, James | - |
dc.contributor.author | Mayur, Prashanth | - |
dc.contributor.author | Harris, Anthony W. F. | - |
dc.date.accessioned | 2024-01-23T01:00:12Z | - |
dc.date.available | 2024-01-23T01:00:12Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Asian Journal of Psychiatry 92:103895, 2024 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8354 | - |
dc.description.abstract | OBJECTIVE: There are few studies that examine the effectiveness of Continuation/Maintenance Electroconvulsive Therapy (C/M-ECT) in schizophrenia, despite the documented effectiveness of acute ECT treatment. We aimed to investigate the clinical effectiveness of C/M-ECT for in-patients with Schizophrenia in a naturalistic setting. We examined the medical records of 46 in-patients who were diagnosed with Schizophrenia and had received C/M-ECT belonging to non-acute extended care service in a public psychiatry hospital in Sydney, Australia. The focus of analysis was on 138 treatment cycles (71 acute only cycles and 67 acute-continuation/maintenance cycles) across 45 subjects. A linear mixed effects model was used to describe the change in clinical global impression-severity (CGI-S) over time 4 time points viz., pre-post acute and pre-post continuation/maintenance ECT. RESULTS: Acute-only cycles and acute-continuation/maintenance cycles had identical pre- (M = 5, C.I. = 4-6), post-cycle CGI-S scores, and identical CGI-S difference scores (M = 0, C.I. = -1 - 1). Broadly in each continuation/maintenance cycle, we observed an initial sharp decrease in CGI-S scores followed by a logarithmic increase in scores over time, with satisfactory CGI-S score maintenance observed for approximately 6 months. Bitemporal ECT influenced CGI-S across maintenance ECT (p < 0.05) indicating smaller declines in CGI-S scores over time. CONCLUSIONS: In schizophrenia, C/M ECT preserves effects on illness severity for at least upto 6 months following an acute course of ECT. Bitemporal ECT vis a vis other electrode positions differentiated clinical severity over time. | - |
dc.title | Examining the clinical effectiveness of continuation and maintenance electroconvulsive therapy in schizophrenia | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1016/j.ajp.2023.103895 | - |
dc.subject.keywords | Bitemporal ECT | - |
dc.subject.keywords | Continuation ECT | - |
dc.subject.keywords | ECT | - |
dc.subject.keywords | Maintenance ECT | - |
dc.subject.keywords | Naturalistic | - |
dc.subject.keywords | Schizophrenia | - |
dc.identifier.journaltitle | Asian Journal of Psychiatry | - |
dc.identifier.department | Mental Health | - |
dc.identifier.department | Statistical Support | - |
dc.contributor.wslhd | George, Rachna | - |
dc.contributor.wslhd | Krishnan, Vijay | - |
dc.contributor.wslhd | Talbot, Daniel | - |
dc.contributor.wslhd | Elhindi, James | - |
dc.contributor.wslhd | Mayur, Prashanth | - |
dc.contributor.wslhd | Harris, Anthony W. F. | - |
dc.type.studyortrial | Cohort Analysis | - |
dc.identifier.pmid | 38157717 | - |
dc.identifier.affiliation | University of Sydney, Australia | - |
dc.identifier.affiliation | Western Sydney Local Health District, Westmead, NSW, Australia | - |
dc.identifier.facility | Blacktown | - |
dc.identifier.facility | Westmead | - |
dc.identifier.facility | Mental Health, Cumberland | - |
Appears in Collections: | Blacktown Mount Druitt Hospital |
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