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DC Field | Value | Language |
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dc.contributor.author | Geevasinga, Nimeshan | - |
dc.contributor.author | Howells, James | - |
dc.contributor.author | Menon, Parvathi | - |
dc.contributor.author | van den Bos, Mehdi | - |
dc.contributor.author | Shibuya, Kazumoto | - |
dc.contributor.author | Matamala, Jose Manuel | - |
dc.contributor.author | Park, Susanna B. | - |
dc.contributor.author | Byth, Karen | - |
dc.contributor.author | Kiernan, Matthew C. | - |
dc.contributor.author | Vucic, Steve | - |
dc.date.accessioned | 2024-02-09T00:43:38Z | - |
dc.date.available | 2024-02-09T00:43:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Neurology 92(6):e536-e547, 2019 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8583 | - |
dc.description.abstract | OBJECTIVE: The aim of the study was to assess the utility of a novel amyotrophic lateral sclerosis (ALS) diagnostic index (ALSDI).METHODS: A prospective multicenter study was undertaken on patients presenting with suspected ALS. The reference standard (Awaji criteria) was applied to all patients at recruitment. Patients were randomly assigned to a training (75%) and a test (25%) cohort. The ALSDI was developed in the training cohort and its diagnostic utility was subsequently assessed in the test cohort.RESULTS: A total of 407 patients were recruited, with 305 patients subsequently diagnosed with ALS and 102 with a non-ALS mimicking disorder. The ALSDI reliably differentiated ALS from neuromuscular disorders in the training cohort (area under the curve 0.92, 95% confidence interval 0.89-0.95), with ALSDI >=4 exhibiting 81.6% sensitivity, 89.6% specificity, and 83.5% diagnostic accuracy. The ALSDI diagnostic utility was confirmed in the test cohort (area under the curve 0.90, 95% confidence interval 0.84-0.97), with ALSDI >=4 exhibiting 83.3% sensitivity, 84% specificity, and 83.5% diagnostic accuracy. In addition, the diagnostic utility of the ALSDI was confirmed in patients who were Awaji negative at recruitment and in those exhibiting a predominantly lower motor neuron phenotype.CONCLUSION: The ALSDI reliably differentiates ALS from mimicking disorders at an early stage in the disease process.CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that for patients with suspected ALS, the ALSDI distinguished ALS from neuromuscular mimicking disorders. | - |
dc.title | Amyotrophic lateral sclerosis diagnostic index: Toward a personalized diagnosis of ALS | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1212/WNL.0000000000006876 | - |
dc.subject.keywords | Amyotrophic Lateral Sclerosis | - |
dc.subject.keywords | Evoked Potentials, Motor | - |
dc.subject.keywords | Neural Inhibition | - |
dc.subject.keywords | Neuromuscular Diseases | - |
dc.subject.keywords | Transcranial Magnetic Stimulation | - |
dc.identifier.journaltitle | Neurology | - |
dc.contributor.wslhd | Geevasinga, Nimeshan | - |
dc.contributor.wslhd | Howells, James | - |
dc.contributor.wslhd | Menon, Parvathi | - |
dc.contributor.wslhd | van den Bos, Mehdi | - |
dc.contributor.wslhd | Shibuya, Kazumoto | - |
dc.contributor.wslhd | Matamala, Jose Manuel | - |
dc.contributor.wslhd | Park, Susanna B. | - |
dc.contributor.wslhd | Byth, Karen | - |
dc.contributor.wslhd | Kiernan, Matthew C. | - |
dc.contributor.wslhd | Vucic, Steve | - |
dc.type.studyortrial | Research Support, Non-U.S. Gov't | - |
dc.identifier.pmid | 30709964 | - |
dc.identifier.facility | Westmead | - |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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