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DC Field | Value | Language |
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dc.contributor.author | Valenzuela-Vallejo, L. | - |
dc.contributor.author | Chrysafi, P. | - |
dc.contributor.author | Kouvari, M. | - |
dc.contributor.author | Guatibonza-Garcia, V. | - |
dc.contributor.author | Mylonakis, S. C. | - |
dc.contributor.author | Katsarou, A. | - |
dc.contributor.author | Verrastro, O. | - |
dc.contributor.author | Markakis, G. | - |
dc.contributor.author | Eslam, Mohammed | - |
dc.contributor.author | Papatheodoridis, G. | - |
dc.contributor.author | Mingrone, G. | - |
dc.contributor.author | George, Jacob | - |
dc.contributor.author | Mantzoros, C. S. | - |
dc.date.accessioned | 2024-03-12T04:05:31Z | - |
dc.date.available | 2024-03-12T04:05:31Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Metabolism: Clinical and Experimental 148:155694, 2023 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9060 | - |
dc.description.abstract | BACKGROUND: The role of metabolic/inflammatory hormonal systems in metabolic dysfunction associated steatotic liver disease (MASLD) remains to be fully elucidated. Purpose(s): To report the levels of the novel total and H-specific growth differentiation factor-15 (GDF-15) and other established hormonal systems and to describe hormonal patterns in controls and patients with MASLD and its stages. METHODS: This is a multicenter study from two Gastroenterology-Hepatology Departments (Greece and Australia) and one Bariatric-Metabolic Surgery Department (Italy). Overall, n = 455 serum samples of patients with biopsy-proven MASLD (n = 374) and Controls (n = 81) were recruited. RESULTS: We report for the first time that total and H-specific GDF-15 levels are higher in MASLD, at-risk metabolic dysfunction associated steatohepatitis (MASH), and severe fibrosis than in Controls. In addition, follistatin-like-3 (FSTL-3), free insulin-like growth factor-1 (IGF-1), leptin, and insulin levels were higher in MASLD patients than in Controls, while adiponectin levels were lower in MASLD subjects than in Controls. Activin-A, follistatin (FST), FSTL-3, and insulin levels significantly increased in severe fibrosis compared to no/mild fibrosis, while free IGF-1 decreased. In addition, adiponectin levels were lower in subjects without fibrosis vs. any fibrosis. Moreover, GDF-15 presented a strong positive association for the likelihood of having MASLD and at-risk MASH, while in adjusted analyses, FST and adiponectin showed inverse associations. Two different patterns of at-risk MASH were revealed through unsupervised analysis (total variation explained=54%). The most frequent pattern met in our sample (34.3%) was characterized by higher levels of total and H-specific GDF-15, follistatins, and activins, as well as low adiponectin levels. The second pattern revealed was characterized by high levels of free IGF-1, insulin, and leptin, with low levels of activin-A and adiponectin. Similar patterns were also generated in the case of overall MASLD. CONCLUSIONS: Total and H-specific GDF-15 levels increase as MASLD severity progresses. FSTL-3, free IGF-1, leptin, and insulin are also higher, whereas adiponectin and activin-A levels are lower in the MASLD group than in Controls. Hormonal systems, including GDF-15, may not only be involved in the pathophysiology but could also prove useful for the diagnostic workup of MASLD and its stages and may potentially be of therapeutic value. | - |
dc.subject | Hepatology | - |
dc.title | Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A multicenter observational study | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1016/j.metabol.2023.155694 | - |
dc.subject.keywords | bariatric surgery | - |
dc.subject.keywords | diabetes mellitus | - |
dc.subject.keywords | fatty liver | - |
dc.subject.keywords | fibrosis | - |
dc.subject.keywords | gastroenterology | - |
dc.subject.keywords | insulin blood level | - |
dc.subject.keywords | metabolic disorder | - |
dc.subject.keywords | nonalcoholic fatty liver | - |
dc.subject.keywords | nonalcoholic steatohepatitis | - |
dc.subject.keywords | obesity | - |
dc.subject.keywords | protein expression | - |
dc.subject.keywords | surgery | - |
dc.subject.keywords | adiponectin | - |
dc.subject.keywords | endogenous compound | - |
dc.subject.keywords | follistatin | - |
dc.subject.keywords | growth differentiation factor 15 | - |
dc.subject.keywords | hormone | - |
dc.subject.keywords | insulin | - |
dc.subject.keywords | leptin | - |
dc.subject.keywords | somatomedin C | - |
dc.identifier.journaltitle | Metabolism: Clinical and Experimental | - |
dc.identifier.department | Gastroenterology and Hepatology | - |
dc.identifier.department | Storr Liver Centre | - |
dc.contributor.wslhd | Eslam, Mohammed | - |
dc.contributor.wslhd | George, Jacob | - |
dc.type.studyortrial | Controlled Study | - |
dc.type.studyortrial | Major Clinical Study | - |
dc.type.studyortrial | Multicentre Study | - |
dc.identifier.pmid | 37757973 | - |
dc.identifier.affiliation | Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States | - |
dc.identifier.affiliation | Department of Gastroenterology, Universita Cattolica del Sacro Cuore, Rome, Italy | - |
dc.identifier.affiliation | Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", Athens, Greece | - |
dc.identifier.affiliation | Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia | - |
dc.identifier.affiliation | Department of Medicine, Boston VA Healthcare System, Boston, MA, United States | - |
dc.identifier.facility | Blacktown | - |
dc.identifier.facility | Westmead | - |
Appears in Collections: | Blacktown Mount Druitt Hospital |
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