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Title: | Initial response and 12-month outcomes after commencing dexamethasone or vascular endothelial growth factor inhibitors for retinal vein occlusion in the FRB registry |
Authors: | Garay-Aramburu, G.;Hunt, Adrian;Arruabarrena, C.;Mehta, H.;Invernizzi, A.;Gabrielle, P. H.;Guillaumie, T.;Wolff, B.;Gillies, M. C.;Zarranz-Ventura, J. |
WSLHD Author: | Hunt, Adrian |
Issue Date: | 2024 |
Citation: | Scientific Reports 14(1):6122, 2024 |
Abstract: | To compare baseline characteristics, initial response and 12-month efficacy and safety outcomes in eyes with branch and central retinal vein occlusion (BRVO and CRVO) treated with dexamethasone implants (DEX) or anti-vascular endothelial growth factor (anti-VEGF) we performed a multi-centre, retrospective and observational study using Fight Retinal Blindness! Registry. Of 725 eligible eyes, 10% received DEX initially with very frequent adjunctive anti-VEGF (BRVO-DEX 49%, CRVO-DEX 60%). The primary outcome of mean adjusted change in VA at 12 months with DEX and anti-VEGF initiated groups were not statistically significantly different (BRVO: DEX + 6.7, anti-VEGF + 10.6 letters; CRVO: DEX + 2.8, anti-VEGF + 6.8 letters). DEX initiated eyes had fewer injections and visits than anti-VEGF initiated eyes. The BRVO-DEX eyes had greater initial mean changes in VA and central subfield thickness (CST) and achieved inactivity sooner than BRVO-anti-VEGF eyes. The mean CST after the first three months was above 350 mum in all but the BRVO-anti-VEGF group, suggesting undertreatment. In routine care DEX is uncommonly used when available as initial treatment of BRVO and CRVO requiring supplemental anti-VEGF within the first year. The 12-month outcomes were similar, but DEX initiated eyes had fewer injections and visits but more episodes of raised IOP Vs those starting anti-VEGF. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9390 |
DOI: | https://dx.doi.org/10.1038/s41598-024-56581-6 |
Journal: | Scientific Reports |
Type: | Journal Article |
Study or Trial: | Observational Study |
Department: | Ophthalmology |
Facility: | Westmead |
Keywords: | Retinal Vein Occlusion Dexamethasone Glucocorticoids Vascular Endothelial Growth Factor A Macular Edema Intravitreal Injections |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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