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DC Field | Value | Language |
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dc.contributor.author | Mundisugih, Juan | - |
dc.contributor.author | Kumar, Saurabh | - |
dc.contributor.author | Kizana, Eddy | - |
dc.date.accessioned | 2024-06-04T03:58:47Z | - |
dc.date.available | 2024-06-04T03:58:47Z | - |
dc.date.issued | 2024 | - |
dc.identifier.citation | Heart Rhythm 21(6):939-949, 2024 | - |
dc.identifier.uri | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9728 | - |
dc.description.abstract | Cardiac tachyarrhythmia presents a significant health care challenge, causing notable morbidity and mortality. Conventional treatments have limitations and potential risks, resulting in an elevated disease burden. Adeno-associated virus (AAV)-mediated gene therapy holds promise as a potential future treatment option. Therefore, we aimed to provide a measured overview of the latest developments in this rapidly growing field. PubMed and Embase databases were searched up to January 2024. Studies that employed AAV as a vector for delivery of therapeutic agents to treat cardiac tachyarrhythmia were included. Of the 26 studies included, 20 published in the last 5 years. There were 22 novel molecular targets identified. More than 80% of the included studies employed small-animal models or used AAV9. In atrial fibrillation preclinical studies, AAV-mediated gene therapy reduced atrial fibrillation inducibility by 81% (odds ratio, 0.19 [0.08-0.45]; P < .01). Similarly, for acquired and inherited ventricular arrhythmia, animal models receiving gene therapy had less inducible ventricular arrhythmia (odds ratio, 0.06 [0.03-0.11]; P < .01). This review highlights the rapid progress of AAV-mediated gene therapy for cardiac tachyarrhythmia. Although these investigations are currently in the early stages of clinical application, they present promising prospects for gene therapy. (PROSPERO registry: CRD42023479448)Copyright 2024 Heart Rhythm Society | - |
dc.title | Adeno-associated virus-mediated gene therapy for cardiac tachyarrhythmia: A systematic review and meta-analysis | - |
dc.type | Journal Article | - |
dc.identifier.doi | https://dx.doi.org/10.1016/j.hrthm.2024.02.001 | - |
dc.subject.keywords | Animals | - |
dc.subject.keywords | Dependovirus | - |
dc.subject.keywords | Gene Therapy | - |
dc.subject.keywords | Tachycardia | - |
dc.identifier.journaltitle | Heart Rhythm | - |
dc.contributor.wslhd | Mundisugih, Juan | - |
dc.contributor.wslhd | Kumar, Saurabh | - |
dc.contributor.wslhd | Kizana, Eddy | - |
dc.type.studyortrial | Review | - |
dc.identifier.pmid | 38336191 | - |
dc.identifier.facility | Westmead | - |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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