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https://wslhd.intersearch.com.au/wslhdjspui/handle/1/7263
Title: | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
Authors: | Fabijan, Aleksandra P.;Iredell, Jonathan R.;Danis-Wlodarczyk, K.;Kebriaei, R.;Abedon, S. T. |
WSLHD Author: | Fabijan, Aleksandra P.;Iredell, Jonathan R. |
Issue Date: | 2023 |
Citation: | PLoS biology 21(5):e3002119, 2023 |
Abstract: | Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/7263 |
DOI: | https://dx.doi.org/10.1371/journal.pbio.3002119 |
Journal: | PLoS biology |
Type: | Journal Article |
Study or Trial: | Controlled Study |
Department: | Infectious Diseases |
Facility: | Blacktown Westmead Auburn Mental Health, Cumberland |
Affiliated Organisations: | Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW, Australia Faculty of Health and Medicine, School of Medicine, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia Westmead Hospital, Western Sydney Local Health District, Westmead, NSW, Australia Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA P3 Research Laboratory, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA Department of Microbiology, The Ohio State University, Mansfield, Ohio, USA |
Keywords: | bacterial infection bacteriophage biological pest control phage therapy antibiotic agent |
Appears in Collections: | Blacktown Mount Druitt Hospital |
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