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https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8274
Title: | Definitive treatment with PD-1 blockade and radiation therapy of unresected primary desmoplastic melanoma of the nose |
Authors: | Gjorup, C. A.;da Silva, Ines Pires;Martin, Linda K.;Stretch, J. R.;Scolyer, R. A.;Long, G. V.;Hong, A. |
WSLHD Author: | da Silva, Ines Pires;Martin, Linda K. |
Subjects: | Radiation Oncology |
Issue Date: | 2023 |
Citation: | Melanoma Research 33(5):422-424, 2023 |
Abstract: | Two patients with primary desmoplastic melanoma of the nose were treated with definitive anti-PD-1 checkpoint inhibitor (anti-PD1) and radiation therapy. Both patients were technically resectable with partial rhinectomy but both declined for cosmetic reasons. The melanoma multidisciplinary team recommended that the patients receive PD1 blockade. The initial response to PD-1 blockade was temporary in the first case and partial in the second one. With the addition of high-dose radiotherapy, complete responses were obtained in both patients, with recurrence-free and good functional and cosmetic outcomes at a six-year and 22-month follow-up. Despite surgery being the gold standard, both cases illustrated that PD-1 blockade and radiation therapy can be a safe alternative option for desmoplastic melanoma where surgery is morbidly disfiguring. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8274 |
DOI: | https://doi.org/10.1097/CMR.0000000000000905 |
Journal: | Melanoma Research |
Type: | Journal Article |
Study or Trial: | Case Reports |
Department: | Oncology Radiation Therapy |
Facility: | Westmead Blacktown |
Affiliated Organisations: | Melanoma Institute Australia, The University of Sydney, Sydney, Australia Faculty of Medicine & Health, The University of Sydney, Sydney, Australia Charles Perkins Centre, The University of Sydney, Sydney, Australia Medical Oncology, Blacktown Hospital, Sydney, Australia The University of New South Wales, Sydney, Australia Royal Prince Alfred Hospital and NSW Health Pathology, Tissue Pathology and Diagnostic Oncology, Sydney, Australia Royal North Shore and Mater Hospitals, Medical Oncology, Sydney, Australia |
Keywords: | cancer radiotherapy cancer surgery desmoplastic melanoma immunotherapy multidisciplinary team nose remission programmed death 1 receptor |
Appears in Collections: | Blacktown Mount Druitt Hospital |
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