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https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8817
Title: | Sudden Death Risk-Stratification in 2018-2019: The Old and the New |
Authors: | Zaman, S.;Goldberger, J. J.;Kovoor, Pramesh |
WSLHD Author: | Kovoor, Pramesh |
Issue Date: | 2019 |
Citation: | Heart, Lung & Circulation 28(1):57-64, 2019 |
Abstract: | Sudden Cardiac Death (SCD) is a major public health issue, accounting for half of all cardiovascular deaths world-wide. The implantable cardioverter-defibrillator (ICD) has been solidified as the cornerstone therapy in primary prevention of SCD in ischaemic and non-ischaemic cardiomyopathy. However, what has become increasingly clear is that the left ventricular ejection fraction (LVEF) is an inadequate tool to select patients for a prophylactic ICD, despite its widespread use for this purpose. Use of LVEF alone has poor specificity for arrhythmic versus non-arrhythmic death. In addition, the vast majority of sudden deaths occur in patients with more preserved cardiac function. Alternate predictors of sudden death include electrophysiology study, non-invasive markers of electrical instability, myocardial fibrosis, genetic and bio-markers. The challenge for the future is finding a risk stratification test, or combination of tests, that adequately select patients at high risk of SCD with low competing risk of non-sudden death. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/8817 |
DOI: | https://dx.doi.org/10.1016/j.hlc.2018.08.027 |
Journal: | Heart, Lung & Circulation |
Type: | Journal Article |
Study or Trial: | Review |
Department: | Cardiology |
Facility: | Westmead |
Keywords: | Cardiovascular Diseases Death, Sudden, Cardiac Global Health Incidence Primary Prevention |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
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