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Title: | SAFFRON-103: a phase Ib study of sitravatinib plus tislelizumab in anti-PD-(L)1 refractory/resistant advanced melanoma |
Authors: | Wang, X.;Pan, H.;Cui, J.;Chen, X.;Yoon, Won-Hee;Carlino, Matteo S.;Li, X.;Li, H.;Zhang, J.;Sun, J.;Guo, J.;. |
WSLHD Author: | Yoon, Won-Hee;Carlino, Matteo S. |
Subjects: | Oncology |
Issue Date: | 2024 |
Citation: | Immunotherapy 16(4):243-256, 2024 |
Abstract: | AIM: Investigate TKI sitravatinib plus anti-PD-1 antibody tislelizumab in patients with unresectable/advanced/metastatic melanoma with disease progression on/after prior first-line anti-PD-(L)1 monotherapy. METHODS: Open-label, multicenter, multicohort study (NCT03666143). Patients in the melanoma cohort (N = 25) received sitravatinib once daily plus tislelizumab every 3 weeks. The primary end point was safety and tolerability. RESULTS: Treatment-emergent adverse events (TEAEs) occurred in all patients, with >=grade 3 TEAEs in 52.0%. Most TEAEs were mild-or-moderate in severity, none were fatal, and few patients discontinued treatment owing to TEAEs (12.0%). OBJECTIVE response rate was 36.0% (95% CI: 18.0-57.5). Median progression-free survival was 6.7 months (95% CI: 4.1-not estimable). CONCLUSION: Sitravatinib plus tislelizumab had manageable safety/tolerability in patients with anti-PD-(L)1 refractory/resistant unresectable/advanced/metastatic melanoma, with promising antitumor activity. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9493 |
DOI: | https://dx.doi.org/10.2217/imt-2023-0130 |
Journal: | Immunotherapy |
Type: | Journal Article |
Study or Trial: | Multicentre Study |
Department: | Oncology |
Facility: | Blacktown Westmead |
Affiliated Organisations: | Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing, China Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China The First Hospital of Jilin University, Changchun, China Blacktown Cancer and Haematology Centre, Blacktown, NSW, Australia Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia BeiGene Co., Ltd., Beijing, China BeiGene Co., Ltd., Shanghai, China |
Keywords: | drug therapy, combination immunotherapy melanoma |
Appears in Collections: | Blacktown Mount Druitt Hospital |
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