Please use this identifier to cite or link to this item:
https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9533
Title: | Subclinical myocardial dysfunction is associated with the development of primary cardiovascular outcomes in patients with systemic sclerosis |
Authors: | Khanna, Shaun;Mishra, Shiva R.;Thakur, Arunav;Bhat, Aditya;Chen, Henry H.;Gan, Gary C. H.;Tan, Timothy C. |
WSLHD Author: | Khanna, Shaun;Mishra, Shiva R.;Thakur, Arunav;Bhat, Aditya;Chen, Henry H.;Gan, Gary C. H.;Tan, Timothy C. |
Subjects: | Cardiology |
Issue Date: | 2024 |
Citation: | Journal of the American College of Cardiology 83(13 Supplement):1475, 2024 |
Abstract: | BACKGROUND: Systemic sclerosis (SSc) is a chronic autoimmune condition associated with subclinical myocardial dysfunction. Myocardial strain analysis can predict cardiovascular events in multiple cardiac pathologies. The aim of this study was to assess the prognostic relevance of left ventricular global longitudinal strain (LV-GLS) and right ventricular free wall strain (RV-FWS) in patients with SSc. METHODS: Consecutive patients admitted to our institution with a known history of SSc, without established cardiac disease were included, and followed up for the development of all-cause death and major adverse cardiovascular events (MACE). GLS was performed using TomTec-Arena, Germany v4.6. LV-GLS <-17% and RV-FWS <-23% was considered abnormal. All statistical analysis was performed using SPSS v22. RESULTS: 70 patients (57+/-13 years, 79% female) with complete transthoracic echocardiograms were included. The cohort had a mean LVEF of 63+/-8%, mean TAPSE of 2.0+/-0.5 and a mean mPASP of 33+/-19mmHG. Upon 60 months of follow-up, 21 patients met the primary endpoint (11 death, 10 MACE). 25 patients demonstrated subclinical biventricular impairment (LV-GLS<-17% AND RV-FWS<-23%). The presence of subclinical biventricular impairment was associated with the primary outcome (log-rank, p=0.009). CONCLUSION: Subclinical biventricular dysfunction portends a poor prognosis in patients with SSc. Aggressive anti-remodeling and immunosuppressive therapy in this subgroup may improve their prognosis. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9533 |
DOI: | https://doi.org/10.1016/S0735-1097(24)03465-X |
Journal: | Journal of the American College of Cardiology |
Type: | Journal Article Conference Abstract |
Study or Trial: | Controlled Study Major Clinical Study Retrospective Study |
Department: | Cardiology |
Facility: | Blacktown Westmead |
Affiliated Organisations: | Blacktown Hospital, Sydney, Australia |
Keywords: | cardiomyopathy cardiovascular disease echocardiography heart disease immunosuppressive treatment systemic sclerosis |
Conference name: | American College of Cardiology 73rd Annual Scientific Session AND Expo. Atlanta United States. |
Appears in Collections: | Blacktown Mount Druitt Hospital |
Files in This Item:
There are no files associated with this item.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.