Please use this identifier to cite or link to this item:
https://wslhd.intersearch.com.au/wslhdjspui/handle/1/6713
Title: | EQUAL Score Scedosporiosis/Lomentosporiosis 2021: a European Confederation of Medical Mycology (ECMM) tool to quantify guideline adherence |
Authors: | Stemler, J.;Lackner, M.;Chen, Sharon C-A.;Hoenigl, M.;Cornely, O. A. |
WSLHD Author: | Chen, Sharon C-A. |
Issue Date: | 2021 |
Citation: | Journal of Antimicrobial Chemotherapy 77(1):253-258, 2021 |
Abstract: | BACKGROUND: Invasive scedosporiosis and lomentosporiosis are life-threatening fungal infections in immunocompromised patients with complex diagnostic and treatment patterns. OBJECTIVES: To develop a scoring tool to facilitate and quantify adherence to current guideline recommendations for diagnosis, treatment and follow-up of invasive scedosporiosis and lomentosporiosis. METHODS: Experts from European Confederation of Medical Mycology (ECMM) excellence centres reviewed current guidelines for scedosporiosis and lomentosporiosis. Recommendations for diagnosis, treatment and follow-up were summarized, assembled and weighted according to their strength of recommendation and level of evidence (strongly recommended = 3 points; moderately recommended = 2 points; marginally recommended = 1 point; recommended against = 0 points). Additional items considered of high importance for clinical management were also weighted. RESULTS: A total of 170 recommendations were identified. A 21-item tool was developed and embedded into the EQUAL score card. Nine items for diagnosis with 18 achievable points were assembled. For treatment, three general recommendation items with a maximal score of 9 were identified, while for specific antifungal treatment the two fungal pathogens were separated. Three and four items were established for scedosporiosis and lomentosporiosis, respectively, with a maximum achievable score of 3 due to the separation of different treatment options with the maximum point value of 3 for voriconazole-based treatment. Follow-up comprised two items (4 points maximum). Key recommendations for clinical outcome were weighted accordingly. CONCLUSIONS: We propose the EQUAL Score Scedosporiosis/Lomentosporiosis to quantify adherence to current guideline recommendations for management of these rare infections. The score remains to be validated in real-life patient cohorts and correlated with patient outcome. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/6713 |
DOI: | https://dx.doi.org/10.1093/jac/dkab355 |
Journal: | Journal of Antimicrobial Chemotherapy |
Type: | Journal Article |
Study or Trial: | Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't |
Department: | Infection Prevention and Control |
Facility: | Westmead |
Keywords: | Antifungal Agents Guideline Adherence Invasive Fungal Infections Mycology |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
Files in This Item:
There are no files associated with this item.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.