Please use this identifier to cite or link to this item:
https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9652
Title: | Geographic disparities in access to liver transplant for advanced cirrhosis: Time to ring the alarm! |
Authors: | Bajaj, J. S.;Choudhury, A.;Kumaran, V.;Wong, F.;Seto, W. K.;Alvares-Da-Silva, M. R.;Desalgn, H.;Hayes, P. C.;Idilman, R.;Topazian, M.;Torre, A.;Xie, Q.;George, Jacob;Kamath, P. S. |
WSLHD Author: | George, Jacob |
Issue Date: | 2024 |
Citation: | American Journal of Transplantation 24(5):733-742, 2024 |
Abstract: | Decompensated cirrhosis and hepatocellular cancer are major risk factors for mortality worldwide. Liver transplantation (LT), both live-donor LT or deceased-donor LT, are lifesaving, but there are several barriers toward equitable access. These barriers are exacerbated in the setting of critical illness or acute-on-chronic liver failure. Rates of LT vary widely worldwide but are lowest in lower-income countries owing to lack of resources, infrastructure, late disease presentation, and limited donor awareness. A recent experience by the Chronic Liver Disease Evolution and Registry for Events and Decompensation consortium defined these barriers toward LT as critical in determining overall survival in hospitalized cirrhosis patients. A major focus should be on appropriate, affordable, and early cirrhosis and hepatocellular cancer care to prevent the need for LT. Live-donor LT is predominant across Asian countries, whereas deceased-donor LT is more common in Western countries; both approaches have unique challenges that add to the access disparities. There are many challenges toward equitable access but uniform definitions of acute-on-chronic liver failure, improving transplant expertise, enhancing availability of resources and encouraging knowledge between centers, and preventing disease progression are critical to reduce LT disparities. |
URI: | https://wslhd.intersearch.com.au/wslhdjspui/handle/1/9652 |
DOI: | https://dx.doi.org/10.1016/j.ajt.2024.02.018 |
Journal: | American Journal of Transplantation |
Type: | Journal Article |
Study or Trial: | Review |
Department: | Storr Liver Centre |
Facility: | Westmead |
Keywords: | Liver Transplantation Liver Cirrhosis Health Services Accessibility Healthcare Disparities |
Appears in Collections: | Westmead Hospital 2019 - 2024 |
Files in This Item:
There are no files associated with this item.
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.